The signify constant condition volume of distribution (Vss) for sildenafil is one hundred and five L, indicating distribution into the tissues. Sildenafil and its key circulating N-desmethyl metabolite are both equally around ninety six% bound to plasma proteins. Protein binding is independent of full drug concentrations.
Dette kan spesielt være dersom tabletten tas med et stort eller fett måltid kan absorberingen av virkemiddelet forsinkes. Alkohol kan redusere effekten av potenspillen, og det anbefales derfor ikke at guy tar medisinen i kombinasjon med overdrevne mengder alkohol.
Hearing: Conditions of sudden lessen or loss of Listening to are claimed postmarketing in temporal association with the usage of PDE5 inhibitors, together with VIAGRA. In a few of the scenarios, health-related problems as well as other aspects have been noted that may have also performed a task inside the otologic adverse events.
There was no impact on sperm motility or morphology soon after one a hundred mg oral doses of VIAGRA in healthy volunteers.
Bruk ikke Viagra Reseptfri dersom du er allergisk mot sildenafil eller noen av de andre innholdsstoffene.
The physiologic system of erection from the penis entails launch of nitric oxide (NO) while in the corpus cavernosum all through sexual stimulation.
The imply profiles from the change from baseline in standing systolic blood pressure in topics treated with doxazosin in combination with 50 mg VIAGRA or matching placebo are shown in Figure three.
Denne potenspillen er en behandling for menn som lider av erektil dysfunksjon (impotens) det vil si, manglende evne til å oppnå eller opprettholde en ereksjon som varer lenge nok for tilfredsstillende seksuell nytelse.
Alpha-blockers are occasionally prescribed for prostate troubles or higher hypertension. In certain patients, the use of VIAGRA with alpha-blockers may lead to a drop in blood pressure or to fainting.
It's eliminated predominantly by hepatic metabolism (primarily CYP3A4) and it is converted to an Lively metabolite with Houses similar to the father or mother, sildenafil. Equally sildenafil as well as the metabolite have terminal 50 % life of about 4 hrs.
Manufacture and sale of sildenafil citrate medications is prevalent in China, in which copyright's patent claim is not really extensively enforced.
Minimal Blood Pressure (Hypotension). Sildenafil may well result in a delicate and momentary fall in blood pressure level. You may well be at the next risk In case you have sure health more info and fitness conditions or choose blood pressure level medicines.
Merk: Beslutninger om behandling vurderes i fellesskap av forskriver og pasient underneath konsultasjonen. Den endelige avgjørelsen vil imidlertid alltid være forskriverens.
Doctors need to suggest individuals to stop taking PDE5 inhibitors, like VIAGRA, and find prompt professional medical attention inside the party of unexpected minimize or lack of hearing. These situations, which can be accompanied by tinnitus and dizziness, are already reported in temporal Affiliation into the consumption of PDE5 inhibitors, including VIAGRA.